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Induction of sister chromatid exchanges with hypotonic treatment
Teratogenesis, Carcinogenesis, and Mutagenesis
|January 1, 1990
Abstract:
Hypotonic NaCl solutions and diluted culture medium were tested for induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CA). Hypotonic treatment conditions were found to induce high frequencies of CA and SCEs. However, an increase in SCEs was observed only in cells that also had CA. Possible lesions and mechanisms leading to SCEs and CA are discussed.