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Updated: Jun 19, 2026

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature
Published on: October 30, 2014
Thermodynamic laws apply to brain function
1Washington Center for Psychiatry, NW Suite 104, Washington, DC 20015, USA. rcolbert@salerianbrain.com
Abstract:
Thermodynamic laws and complex system dynamics govern brain function. Thus, any change in brain homeostasis by an alteration in brain temperature, neurotransmission or content may cause region-specific brain dysfunction. This is the premise for the Salerian Theory of Brain built upon a new paradigm for neuropsychiatric disorders: the governing influence of neuroanatomy, neurophysiology, thermodynamic laws. The principles of region-specific brain function thermodynamics are reviewed. The clinical and supporting evidence including the paradoxical effects of various agents that alter brain homeostasis is demonstrated.
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