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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Peripheral Artery Disease I: Introduction

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Coronary Artery Disease II: Pathophysiology

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Atherosclerosis I: Introduction

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Updated: Jun 19, 2026

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

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[Diffuse arterial calcified elastopathy. A case report].

A Zakaria¹, M Kabiri, M Kabbaj

¹Unité de réanimation néonatale, centre national de référence en néonatologie et nutrition, hôpital d'Enfants de Rabat, Bloc S 18, secteur 17 Hay-Riad, Rabat, Morocco. asmae-zakaria@hotmail.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|October 6, 2009

Summary

Diffuse arterial calcified elastopathy is a rare hereditary condition causing arterial wall calcifications. Early diagnosis in infants with unexplained heart failure or renovascular hypertension is crucial.

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Area of Science:

Cardiovascular Medicine
Genetics
Pediatrics

Background:

Diffuse arterial calcified elastopathy (DACE) is a rare hereditary disorder.
Characterized by diffuse arterial wall calcifications, it is prevalent in North Africa and Caucasian regions.
Its incidence may be underestimated, particularly in Morocco.

Observation:

A case of DACE was diagnosed in a 3-month-old infant presenting with cardiogenic shock.
The infant was admitted to a neonatal intensive care unit.

Findings:

Clinical presentation typically involves renovascular hypertension and heart failure symptoms.
A significant risk of sudden death from myocardial infarction is associated with DACE.
Diagnosis should be suspected in infants with unexplained heart failure or renovascular hypertension.

Implications:

Systematic arterial tension measurement, family screening, and ultrasound are vital for early detection.
Prompt diagnosis and management are essential for affected infants.
Current treatment for DACE remains symptomatic.