Related Experiment Video

Updated: Jun 19, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

HD-03/ES: a promising herbal drug for HBV antiviral therapy

Premashis Kar1, Mohammad Asim, Manash Pratim Sarma

  • 1Department of Medicine, Maulana Azad Medical College, New Delhi, India. premashishkar@gmail.com

Antiviral Research
|October 6, 2009
PubMed

Insights

This study found that the herbal molecule HD-03/ES significantly reduced Hepatitis B virus (HBV) DNA and improved liver function in chronic HBV patients. Genotype A showed a better response to HD-03/ES treatment compared to genotype D.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Chronic liver disease, particularly Hepatitis B virus (HBV) infection, poses a significant global health burden.
  • Understanding HBV genotypes is crucial for predicting disease progression and treatment response.
  • Antiviral herbal molecules are being explored as potential therapeutic agents for chronic HBV.

Purpose of the Study:

  • To investigate the genotypes associated with chronic liver disease in HBV patients.
  • To evaluate the efficacy of the antiviral herbal molecule HD-03/ES in treating chronic HBV.
  • To assess the response of different HBV genotypes to HD-03/ES therapy.

Main Methods:

  • A cohort of 51 chronic liver disease patients received HD-03/ES for 6 months.
  • Monthly monitoring of liver function tests and HBV viral load (HBsAg, HBeAg, HBV DNA).
  • Genotyping of HBV using PCR-RFLP at baseline and post-treatment.

Main Results:

  • HD-03/ES therapy led to significant reductions in ALT levels and HBeAg/HBV DNA.
  • Genotype D was prevalent (76.5%), followed by genotype A (33.5%).
  • Patients with genotype A exhibited a significantly sharper decline in viral load compared to genotype D.

Conclusions:

  • The majority of chronic HBV patients in this study were infected with genotype D.
  • HD-03/ES demonstrated therapeutic potential in reducing HBV viral load, with a more pronounced effect observed in genotype A patients.
  • Larger studies are warranted to validate these findings and confirm the therapeutic efficacy of HD-03/ES across different HBV genotypes.
Abstract

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...