Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism: A Randomized Clinical Trial.

JAMA internal medicine·2026

Same author

Effects of Testosterone-Augmented Multimodal Exercise Intervention in Spinal Cord Injury: A Randomized Controlled Trial.

The Journal of clinical endocrinology and metabolism·2026

Same author

Long-term impact of Diabetes Prevention Program interventions on walking endurance.

Frontiers in public health·2025

Same author

Cardiorespiratory fitness is associated with cortical thickness of medial temporal brain areas associated with spatial cognition in young but not older adults.

The European journal of neuroscience·2023

Same author

Androgens and Selective Androgen Receptor Modulators to Treat Functional Limitations Associated With Aging and Chronic Disease.

The journals of gerontology. Series A, Biological sciences and medical sciences·2023

Same author

Exercise and Behavior: Adjuncts to Pro-Myogenic Compounds for Enhancing Mobility in Older Adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2023

Same journal

The Physician Leader: Teaching Leadership in Medicine.

Advances in chronic kidney disease·2022

Same journal

Postgraduate Education and Training for the Nephrology Physician Assistants and Nurse Practitioners.

Advances in chronic kidney disease·2022

Same journal

Evaluation Evolution: Designing Optimal Evaluations to Enhance Learning in Nephrology Fellowship.

Advances in chronic kidney disease·2022

Same journal

Kidney Pathology Education for Nephrology Fellows: Past, Present, and Future.

Advances in chronic kidney disease·2022

Same journal

Clinician Educator Pathway for Nephrology Fellows: The University of North Carolina Experience.

Advances in chronic kidney disease·2022

Same journal

Current Trends and Challenges in Nephrology Fellowship Training: Expansion of Education in Home Dialysis, Palliative Care, and Point-of-Care Ultrasound.

Advances in chronic kidney disease·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Anabolic interventions in ESRD.

Thomas W Storer¹

¹Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118, USA. tstorer@bu.edu

Advances in Chronic Kidney Disease

|October 6, 2009

Summary

This summary is machine-generated.

Resistance exercise may improve muscle strength in patients with end-stage renal disease (ESRD), but effects on lean body mass (LBM) and physical function require further investigation. Optimizing training protocols is key for potential anabolic benefits in ESRD.

Related Experiment Videos

Last Updated: Jun 19, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Exercise Physiology
Muscle Biology

Background:

End-stage renal disease (ESRD) causes muscle atrophy, weakness, and dysfunction due to a chronic catabolic state.
Interventions to counteract muscle loss can significantly enhance the quality of life for ESRD patients.
While endurance exercise shows some anabolic effects, resistance exercise is more potent for stimulating muscle growth and improving performance.

Purpose of the Study:

To evaluate the efficacy of resistance exercise training as an anabolic intervention in patients with end-stage renal disease (ESRD).
To investigate the impact of resistance training on lean body mass (LBM), muscle strength, and physical function in ESRD.
To identify potential limitations in previous studies, such as duration, training load, and sample size, that may have affected outcomes.

Main Methods:

Review of controlled trials investigating resistance exercise training in ESRD patients.
Analysis of studies measuring changes in LBM, muscle strength, and physical function.
Consideration of factors influencing the effectiveness of resistance training interventions.

Main Results:

Previous resistance training studies in ESRD patients have yielded equivocal results regarding significant changes in LBM.
Some studies indicate improvements in other markers of anabolism and typical increases in muscle strength.
Improvements in physical function, whether objectively measured or self-reported, remain inconsistent across studies.

Conclusions:

Resistance exercise training shows promise for improving muscle strength in ESRD patients, but its impact on LBM and physical function needs further research.
Optimizing study durations, training loads, and sample sizes may be crucial for detecting more substantial benefits.
While androgens and growth hormone show potential for improving LBM and strength, their long-term safety and efficacy in ESRD require more investigation before widespread recommendation.