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Updated: Jun 19, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
Published on: January 18, 2014
ScoC regulates bacilysin production at the transcription level in Bacillus subtilis
Takashi Inaoka1, Guojun Wang, Kozo Ochi
1National Food Research Institute, Tsukuba, Ibaraki, Japan. tina2672@affrc.go.jp
Abstract:
Bacillus subtilis mutants with high expression of the bacilysin operon ywfBCDEFG were isolated. Comparative genome sequencing analysis revealed that all of these mutants have a mutation in the scoC gene. The disruption of scoC by genetic engineering also resulted in increased expression of ywfBCDEFG. Primer extension and gel mobility shift analyses showed that the ScoC protein binds directly to the promoter region of ywfBCDEFG. Our results indicate that the transition state regulator ScoC, together with CodY and AbrB, negatively regulates bacilysin production in B. subtilis.
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