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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii
David Dako Chiozem1, Hanh Trinh-Van-Dufat, Jean Duplex Wansi
1Laboratoire de Synthèse et de Substances Naturelles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences, Cameroon.
Abstract:
Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some gram-positive and gram-negative bacteria, and they appeared to be modestly active.
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