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Updated: Aug 9, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Modulation of antitumour drug resistance: experimental laboratory data and results of clinical evaluation

B T Hill1

  • 1Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund Laboratories, London, UK.

Cancer Treatment Reviews
|September 1, 1990
PubMed

Insights

Laboratory research offers new strategies to overcome antitumour drug resistance. Clinical evaluations and upcoming Phase I studies will test novel therapeutic agents to improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Research

Background:

  • Antitumour drug resistance is a major challenge in cancer therapy.
  • Laboratory studies have identified potential mechanisms to overcome this resistance.

Purpose of the Study:

  • To explore novel strategies for modulating antitumour drug resistance.
  • To evaluate promising approaches in clinical settings.

Main Methods:

  • Review of laboratory findings on drug resistance modulation.
  • Clinical evaluation of selected strategies.
  • Planning of Phase I clinical trials for new agents.

Main Results:

  • Several promising strategies for overcoming drug resistance have emerged from laboratory research.
  • Initial clinical evaluations have been conducted on some of these strategies.

Conclusions:

  • Laboratory findings provide a strong basis for clinical investigation.
  • Further clinical studies, including Phase I trials, are warranted to assess new agents targeting drug resistance.

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