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Updated: Jun 19, 2026

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Urinary uric acid in preterm neonates.

Pallab Basu¹, Sabyasachi Som, Nabendu Choudhuri

¹Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, West Bengal, India. basu_pallab@yahoo.co.in

Indian Journal of Pediatrics

|October 6, 2009

Summary

Preterm neonates have higher uric acid levels in urine on day one compared to term babies. Urinary uric acid levels are inversely related to body weight and gestational age in these newborns.

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Biochemical Measurement of Neonatal Hypoxia

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Published on: November 20, 2015

Area of Science:

Neonatal physiology
Urine analysis
Biochemistry

Background:

Uric acid is a key metabolic byproduct.
Understanding neonatal uric acid levels is crucial for assessing kidney function and metabolic status.
Preterm infants present unique physiological challenges compared to term infants.

Purpose of the Study:

To determine the uric acid levels in spot urine of preterm, appropriate-for-gestational-age (AGA) neonates on their first day of life.
To compare these levels with those of normal term infants.
To investigate the correlation between urinary uric acid levels and neonatal body weight or gestational age.

Main Methods:

Spot urine samples were collected from 45 normal preterm neonates within 24 hours of birth.
Uric acid levels were estimated in the collected urine samples.
Statistical analysis was performed to compare groups and assess correlations.

Main Results:

The mean uric acid level in preterm neonates was significantly higher (36.50 +/- 5.99 mg/dl) than in normal term babies (18.40 +/- 0.45 mg/dl) (p < 0.001).
A significant negative linear correlation was observed between body weight and urinary uric acid levels (r = -0.970, P < 0.001).
Urinary uric acid levels were inversely proportional to gestational age.

Conclusions:

Normal preterm neonates exhibit higher urinary uric acid levels on day one compared to normal term neonates.
Urinary uric acid levels in neonates are inversely related to body weight and gestational age.
These findings highlight potential differences in uric acid metabolism or renal handling between preterm and term infants.