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[Cirrhotic cardiomyopathy]

M Seirafi1, L Spahr

  • 1Service de gastroentérologie et hepatologie, HUG, 1211 Genève 14. mariam.seirafi@hcuge.ch

Revue Medicale Suisse
|October 7, 2009
PubMed

Insights

Cirrhotic cardiomyopathy involves heart structure and function changes in cirrhosis patients. These cardiac issues are often hidden until stress, but liver transplantation may offer reversibility.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Context:

  • Cirrhosis is a chronic liver disease.
  • Cirrhotic cardiomyopathy presents cardiac abnormalities in liver disease patients.
  • Cardiac dysfunction is often subclinical until physiological stress.

Purpose:

  • To review the physiopathological mechanisms of cirrhotic cardiomyopathy.
  • To discuss the clinical impacts and management options.
  • To highlight potential reversibility after liver transplantation.

Summary:

  • Cirrhotic cardiomyopathy is characterized by cardiac structural and functional abnormalities in cirrhosis patients without other cardiac diseases.
  • Key features include systolic/diastolic dysfunction and electrophysiological changes, often latent until stressed.
  • Pathogenesis involves impaired beta-adrenergic signaling and enhanced cardio-depressor pathways.

Impact:

  • Understanding cirrhotic cardiomyopathy is crucial for managing liver disease patients.
  • Early identification and management can prevent overt cardiac failure.
  • Liver transplantation shows potential for reversing cardiac dysfunction.

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