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Chronic Inflammation: Introduction01:12

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Updated: Jun 19, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

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Published on: August 8, 2014

[Damage-associated molecular patterns and chronic diseases].

Hong-Zhen Yang1, Wen-Feng Cai, Zhuo-Wei Hu

  • 1Institute of Meteria Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|October 7, 2009
PubMed
Summary
This summary is machine-generated.

Damage-associated molecular patterns (DAMPs) are released by stressed cells and trigger immune responses. Understanding DAMPs is crucial for developing new treatments for chronic diseases like arthritis and cancer.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Pathology

Context:

  • Damage-associated molecular patterns (DAMPs) are endogenous molecules released from stressed, damaged, or dying cells.
  • These molecules signal danger to the immune system, influencing immune tolerance and autoimmunity.
  • DAMPs are implicated in the pathogenesis of chronic inflammatory and autoimmune diseases.

Purpose:

  • To define Damage-associated molecular patterns (DAMPs) and their role in cellular stress responses.
  • To elucidate the mechanisms by which DAMPs interact with pattern recognition receptors.
  • To highlight the significance of DAMPs in chronic diseases and potential therapeutic strategies.

Summary:

  • DAMPs are released by cells under stress and are recognized by receptors like Toll-like receptors, Nod1-like receptors, and Rig-I-like receptors.
  • Examples of DAMPs include high-mobility group B protein 1, heat shock proteins, and S100 proteins.
  • Their recognition by the immune system can lead to either autoimmunity or immune tolerance, impacting chronic disease development.

Impact:

  • Identification and mechanistic understanding of DAMPs are key to unraveling chronic disease pathology.
  • DAMPs offer novel targets for diagnostic and therapeutic interventions in diseases such as arthritis, atherosclerosis, cancer, and systemic lupus erythematosus.
  • Further research into DAMPs promises new strategies for disease prevention and treatment.