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Related Experiment Video

Updated: Jun 19, 2026

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
07:40

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Published on: May 16, 2018

Ovarian cortical transplantation.

Gerson Weiss1

  • 1Department of Obstetrics, Gynecology and Women's Health, UMD-New Jersey Medical School, 185 South Orange Avenue, MSB-E506, Newark, NJ 07103, USA. weissge@umdnj.edu.

Women'S Health (London, England)
|October 7, 2009
PubMed
Summary

Ovarian cortical transplantation offers a potential alternative to hormone therapy for early climacterium. This surgical approach in a 46-year-old patient showed no menopausal symptoms and evidence of ovarian function for 18 months.

Area of Science:

  • Reproductive endocrinology
  • Surgical innovation
  • Menopause management

Background:

  • Early climacterium presents challenges in hormone replacement therapy.
  • Bilateral salpingo-oophorectomy can induce premature menopause.
  • Ovarian function preservation is crucial for quality of life.

Purpose of the Study:

  • To evaluate ovarian cortical transplantation as an alternative to hormone therapy.
  • To assess the long-term efficacy of autologous ovarian cortical strips.
  • To monitor hormonal levels and ovarian activity post-transplantation.

Main Methods:

  • Ovarian cortical transplantation of fresh autologous strips.
  • Hormonal assays (FSH, LH, estradiol) at 3-month intervals.
  • Clinical assessment for menopausal symptoms over 18 months.

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Last Updated: Jun 19, 2026

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
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Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Published on: May 16, 2018

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Main Results:

  • The patient experienced no menopausal symptoms for 18 months post-surgery.
  • Hormonal levels fluctuated between premenopausal and postmenopausal ranges.
  • Evidence of folliculogenesis and ovulation was observed.

Conclusions:

  • Ovarian cortical transplantation may be a viable alternative to hormone therapy for early climacterium.
  • Autologous ovarian cortical grafts can restore partial ovarian function.
  • Further research is warranted to confirm these findings.