Hormones in the treatment of depression

Several treatment strategies have been proposed for the management of depression in women. The occurrence of depression among females is often associated with periods of intense hormonal fluctuations, as observed in cases of premenstrual dysphoria, perinatal depression and with the development of depressive symptoms during the perimenopause. Various hormones including estrogen, progesterone, testosterone, dehydroepiandrosterone and thyroid hormones may exert modulatory effects on neurotransmitter pathways in the CNS. It has been postulated that abrupt changes in these hormones may negatively affect mood; conversely, hormonal interventions could potentially improve such symptoms. This article reviews the current literature on the impact of hormonal treatments for mood symptoms in women and preventative strategies for depression in women during the reproductive lifecycle.