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Updated: Jun 19, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Current state of hormone replacement therapy: the case for using trimegestone
1George Eliot Hospital, Nuneaton, Warwickshire, CV10 7DJ, UK. may.wahab@geh.nhs.uk.
Abstract:
Estrogen deficiency has a negative impact on the quality of life of postmenopausal women and is associated with vasomotor symptoms, insomnia and emotional lability. Other manifestations of estrogen deficiency include dry skin, dry vagina and dyspareunia, in addition to bone loss. Estrogen replacement effectively reverses these changes. The only indication for the administration of a progestogen is to protect the postmenopausal uterus against the potential development of endometrial hyperplasia and carcinoma.
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