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[Comparative clinical studies of oral premedication in childhood with reference to various pharmaceuticals]
H J König1, R Honkisch, A Rose
1Abteilung für Anästhesie und Intensivtherapie, Einheit Kreiskrankenhaus/Kreispoliklinik Burg.
Insights
Oral pre-medication in children effectively manages anxiety and anesthesia needs. While several drugs showed similar results, diazepam appeared most effective, especially for younger children.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
Background:
- Pre-medication is crucial for managing pediatric anxiety and improving anesthetic conditions.
- Evaluating different oral pre-medication options is essential for optimizing pediatric care.
Purpose of the Study:
- To investigate the efficacy of oral pre-medication in children aged 1-14.
- To compare the effects of diazepam, promazine, promethazine, and chlorphenethazine on psychic condition and anesthetic measures.
- To assess heart rate, salivation inhibition, and side effects.
Main Methods:
- A randomized prospective study involving 206 children (1-14 years old).
- Administration of oral pre-medication: diazepam (0.3 mg/kg), promazine (1.0 mg/kg), promethazine (1.0 mg/kg), and chlorphenethazine (1.0 mg/kg).
- Evaluation of psychic condition, anesthetic requirements, heart rate, salivation, and side effects.
Main Results:
- No statistically significant differences were found between the drugs for the primary criteria.
- Diazepam generally showed the best outcomes.
- Younger children (1-6 years) sometimes exhibited insufficient pre-medication effects.
- The method was well-tolerated by most children.
Conclusions:
- Oral pre-medication is a valuable and practical method for pediatric anesthesia.
- Diazepam may offer superior results, particularly in younger pediatric patients.
- Further research may be needed to optimize pre-medication strategies for different age groups.
Abstract:
In a randomized prospective study of 206 children aged between one and 14, the influence of oral praemedication on the psychic condition and with regard to anaesthesiologic measures was investigated. Heart rate, inhibition of salivation and the kind and frequency of side-effects were also examined. The praemedication was carried out using diazepam (0.3 mg/kg), promazin (1.0 mg/kg), promethazin (1.0 mg/kg) and chlorphenaethazin (1.0 mg/kg). It was not possible to determine statistically relevant differences between the various drugs concerning the fixed criteria. In general, however, diazepam seems to achieve the best results. In the younger children (1 to 6 years) a frequent and insufficient effect of praemedication was noted immediately. Oral praemedication proved to be a valuable and practicable method which was well tolerated by the great majority of the children.