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Updated: Jun 19, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein(a) as a cardiovascular risk factor.
Christos S Katsouras1, Loukas D Tsironis, Moses Elisaf
1University of Ioannina, Department of Cardiology, 45110 Ioannina, Greece. cskats@yahoo.com
Future Cardiology
|October 7, 2009
Summary
Lipoprotein(a) [Lp(a)] is an emerging cardiovascular disease risk factor. High Lp(a) levels correlate with atherosclerosis and thrombosis, but specific lowering treatments are lacking.
Area of Science:
- Cardiology
- Lipidology
- Vascular Biology
Background:
- Lipoprotein(a) [Lp(a)] is increasingly recognized as a significant risk factor for atherosclerosis and thrombosis.
- Elevated Lp(a) levels, particularly with small apolipoprotein(a) isoforms, are linked to preclinical vascular changes and acute coronary syndromes.
Purpose of the Study:
- To review the current evidence on the role of Lp(a) in cardiovascular disease (CVD).
- To discuss the clinical implications of Lp(a) measurement in at-risk populations.
Main Methods:
- Literature review of recent studies on Lp(a) and cardiovascular outcomes.
- Analysis of the association between Lp(a) levels, particle characteristics, and clinical presentation of coronary artery disease.
Main Results:
- Strong evidence supports Lp(a) as an emerging lipid risk factor for CVD.
- High Lp(a) is associated with preclinical vascular changes and increased risk of acute coronary syndromes.
- No randomized clinical trials targeting Lp(a) lowering agents are currently available.
Conclusions:
- Lp(a) is a critical emerging risk factor for cardiovascular disease.
- Measurement of Lp(a) may benefit individuals with elevated cardiovascular risk, especially those with high LDL cholesterol.
- Population-wide screening for Lp(a) is not currently recommended.
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