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The ASTEROID trial: coronary plaque regression with high-dose statin therapy
Adnan K Chhatriwalla1, Stephen J Nicholls, Steven E Nissen
1The Cleveland Clinic, Desk F-15, 9500 Euclid Avenue, Cleveland, OH 44195, USA. chhatra@ccf.org
Future Cardiology
|October 7, 2009
Summary
High-dose rosuvastatin therapy significantly reduced coronary atheroma burden in patients with coronary artery disease. This intensive lipid-lowering approach may promote atheroma regression, suggesting potential clinical benefits.
Area of Science:
- Cardiology
- Pharmacology
- Medical Imaging
Background:
- Coronary artery disease (CAD) involves the buildup of atherosclerotic plaque.
- Statins are primary agents for lipid management in CAD.
- The impact of high-dose statin therapy on atheroma progression requires further elucidation.
Purpose of the Study:
- To evaluate the effect of high-dose rosuvastatin on coronary atheroma burden.
- To assess changes in atheroma progression using intravascular ultrasound (IVUS).
Main Methods:
- The ASTEROID trial enrolled 349 patients with CAD.
- Patients received rosuvastatin 40 mg/day for 24 months.
- Serial IVUS imaging was performed at baseline and 24 months.
Main Results:
- Rosuvastatin significantly reduced LDL cholesterol to 60.8 mg/dL.
- High-density lipoprotein cholesterol increased by 14.7%.
- All IVUS-derived measures of atheroma burden showed significant reduction.
Conclusions:
- Intensive lipid modification with high-dose rosuvastatin promotes atheroma regression.
- Further research is needed to link atheroma regression to reduced clinical events.
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