Can vascular closure devices reduce complications?

Vascular closure devices have demonstrated their ability to reduce hemostasis and ambulation times, as well as improve patient comfort, without increasing vascular complications in their initial industry-sponsored, randomized clinical trials. However, in the early years of first-generation closure devices, there was an initial concern about the risk of higher complication rates. As devices have improved, it appears that there may now be a trend towards reduced vascular complications compared with manual compression, especially in patients undergoing percutaneous coronary interventions.