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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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Clinical implications of vulnerable plaque.

Jeffrey S Berger1, John L Petersen, James E Tcheng

  • 1Duke University Medical Center, Durham, NC, USA. jeffrey.berger@duke.edu

Future Cardiology
|October 7, 2009
PubMed
Summary

Identifying vulnerable plaques and patients is key to reducing deaths from coronary artery disease (CAD). New imaging tools improve risk assessment for better treatment strategies against this leading cause of mortality.

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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Atherosclerosis Research

Background:

  • Coronary artery disease (CAD) remains the leading cause of death in the USA, often presenting as fatal acute heart attacks.
  • Despite advances in medical therapy and interventional cardiology, mortality rates from CAD persist.
  • Identifying vulnerable plaques and patients is crucial for effective disease management.

Purpose of the Study:

  • To highlight the importance of identifying vulnerable plaques and patients in combating coronary artery disease.
  • To discuss the role of advancements in diagnostic studies and novel imaging tools.
  • To emphasize the potential for improved risk stratification in managing CAD.

Main Methods:

  • Review of current diagnostic studies and novel imaging technologies for plaque vulnerability.
  • Analysis of risk stratification methods, both noninvasive and invasive.
  • Discussion on the implications for systemic and local treatment strategies.

Main Results:

  • Improved diagnostic capabilities and imaging tools offer significant advances in vulnerable plaque management.
  • Enhanced risk stratification allows for better assessment of risk/benefit for novel therapies.
  • Accurate identification of vulnerable plaque can guide more effective systemic and local treatments.

Conclusions:

  • Identifying vulnerable plaques and patients is essential for reducing morbidity and mortality associated with coronary artery disease.
  • Advancements in imaging and diagnostics are critical for improving patient outcomes.
  • Targeted treatments based on plaque vulnerability assessment hold promise for future therapeutic strategies.