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Acute dystonic reaction in normal humans caused by catecholamine depletion
U D McCann1, D M Penetar, G Belenky
1Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Clinical Neuropharmacology
|December 1, 1990
Abstract:
Five of 24 (21%) normal men (volunteers) administered alpha-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.