Related Experiment Video
Updated: Jun 19, 2026

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
Published on: May 22, 2017
Cyclic nucleotide-gated channels: a familiar channel family with a new function?
1The Chinese University of Hong Kong, Department of Physiology & Li Ka Shing Insitute of Health Sciences, Faculty of Medicine, Hong Kong, China. chingon.wong@gmail.com
Abstract:
The cyclic nucleotide-gated (CNG) channel is a family of nonselective cation channels that open in response to an elevated cyclic nucleotide level. Cyclic nucleotides, particularly cAMP and cGMP, govern a great diversity of cellular functions. While the pivotal roles of CNG channels in the visual and olfactory systems have been well established in the past decade, relatively few studies were performed regarding the functional roles of CNG channels in non-neuronal systems. Cyclic nucleotides and Ca2+ are key signaling molecules in cardiovascular systems. Given that CNG channels are expressed in vascular tissues, several recent studies have explored the possible functional role of CNG channels in cardiovascular systems. This article intends to summarize some recent developments regarding the expression and functional role of CNG channels in the cardiovascular system.
More Related Videos
08:31FM Dye Cycling at the Synapse: Comparing High Potassium Depolarization, Electrical and Channelrhodopsin Stimulation
Published on: May 24, 2018
07:04Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins
Published on: February 7, 2020
Related Concept Videos
Channel Rhodopsins
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
G-Protein Gated Ion Channels
Sensory organs,...
Activation and Inactivation of G Proteins
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Photoreceptors and Visual Pathways
Ligand-gated Ion Channels
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...