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Updated: Jun 19, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Novel methods to assess heart valve disease
Andrew C Y To1, Ralph Ah Stewart
1Green Lane Cardiovascular Service, Auckland City Hospital, Level 3, Building 32, Private Bag 92 189 Auckland 1030, New Zealand.
Abstract:
Optimal timing of surgery for heart valve disease relies on the accurate assessment of symptoms, lesion severity, cardiac function and the risks of disease progression. Recent studies suggest potential roles for new echocardiographic techniques, including tissue Doppler and strain imaging at rest or after exercise stress, cardiac magnetic resonance imaging and biomarkers such as B-type natriuretic peptide. These techniques may identify patients at higher risk of symptomatic deterioration or adverse clinical events, and improve the cost-effectiveness and reliability of follow-up.
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S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
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