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Effect of cefatrizine and cephaloglycine on L-leucine absorption in rat jejunum
M V Mendizabal1, I Idoate, J Larralde
1Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, España.
Abstract:
1. The oral cephalosporins: cefatrizine and cephaloglycine inhibit the L-leucine absorption in vivo on rat jejunum. 2. This inhibition is dose and time dependent and the effect is irreversible. 3. These antibiotics have a systemic effect on L-leucine absorption. 4. The inhibition of these antibiotics affect only leucine transport, without affecting the diffusion. 5. Cefatrizine and cephaloglycine inhibit the basolateral (Na(+)-K+) ATPase activity in rat jejunum.