Related Experiment Video
Updated: Jun 19, 2026

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
Published on: June 29, 2022
Idiopathic premature ventricular contractions exhibiting preferential conduction within the aortic root
Takumi Yamada1, Yukihiko Yoshida, Yasuya Inden
1Division of Cardiovascular Disease, University of Alabama at Birmingham, VH B147, 1670 University Boulevard, 1530 3rd Avenue S, Birmingham, AL 35294-0019, USA. takumi-y@fb4.so-net.ne.jp
Premature ventricular contractions (PVCs) originating from the aortic root can be challenging to locate. Ablation in the left coronary cusp was successful, suggesting variable activation patterns influence diagnosis.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Arrhythmias
Background:
- Premature ventricular contractions (PVCs) are common arrhythmias.
- Aortic root ectopy can present diagnostic challenges.
- Electrophysiological testing is crucial for identifying arrhythmia origins.
Observation:
- A patient with frequent PVCs showed an excellent pace map from the right coronary cusp (RCC).
- Radiofrequency ablation at the RCC provided only transient PVC interruption.
- Successful ablation was achieved in the left coronary cusp, with earlier ventricular activation noted there during PVCs compared to the RCC.
Findings:
- Ventricular arrhythmias originating from the aortic root may exhibit variable activation patterns.
- Preferential conduction pathways might exist within the aortic root.
- Electrocardiographic algorithms and pace mapping may have limited reliability for aortic root VAs.
Implications:
- Understanding variable conduction in the aortic root is key for successful ablation.
- New diagnostic strategies may be needed for complex ventricular arrhythmias.
- This case highlights the importance of detailed electrophysiological mapping in challenging cases.
Related Concept Videos
Conduction System of the Heart
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Conduction System of the Heart
This system relies on the unique properties of nodal and Purkinje cells:...
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Dysrhythmias III: Characteristics of Dysrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
