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Related Experiment Video

Updated: Jun 19, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

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Published on: December 21, 2019

Explaining Alberta's rising mesothelioma rates.

M Cree1, M Lalji, B Jiang

  • 1Alberta Health Services, Edmonton, Alberta, Canada. mcree@ualberta.ca

Chronic Diseases in Canada
|October 7, 2009
PubMed
Summary

Mesothelioma incidence in Alberta is linked to asbestos exposure, particularly for men born between 1930-1939. Future pleural mesothelioma deaths are predicted to increase significantly, highlighting the need for surveillance.

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Area of Science:

  • Epidemiology
  • Occupational Health
  • Cancer Research

Background:

  • Mesothelioma incidence is rising globally, but trends in Alberta remain understudied.
  • Asbestos exposure is a primary risk factor for mesothelioma.
  • Understanding temporal trends is crucial for public health interventions.

Purpose of the Study:

  • To model age-period-cohort trends in male pleural mesothelioma incidence in Alberta.
  • To predict future mesothelioma mortality in Alberta.
  • To inform strategies for preventing occupational cancers.

Main Methods:

  • Population-based descriptive study utilizing Alberta Cancer Board Registry data (1980-2004).
  • Development of an age-period-cohort model for male pleural mesothelioma incidence.
  • Analysis of age and cohort effects on incidence rates.

Main Results:

  • Both age and cohort effects significantly influence mesothelioma incidence rates.
  • Men born between 1930 and 1939 represent the highest-risk cohort, linked to 1940s asbestos use in Canada.
  • An estimated 1393 Albertan men aged 40+ will die from pleural mesothelioma between 1980-2024, with 56.2% occurring from 2010-2024.

Conclusions:

  • Mesothelioma mortality in Alberta is projected to rise, peaking between 2015-2019 when all demographics are considered.
  • Continued efforts to eliminate asbestos-related diseases are essential.
  • Implementing robust surveillance systems is critical to prevent future occupational cancer epidemics.