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A 10-year retrospective study on palladium sensitivity.

Olayemi Durosaro1, Rokea A el-Azhary

  • 1Department of Dermatology and Mayo Medical School, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|October 7, 2009
PubMed
Summary
This summary is machine-generated.

Palladium allergy is increasingly common, affecting 12.1% of patients in a US study. Oral conditions like stomatitis were more frequently linked to palladium sensitivity than skin conditions.

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Area of Science:

  • Allergy and Immunology
  • Dermatology
  • Toxicology

Background:

  • Palladium is a growing contact allergen due to its widespread use in industry, jewelry, and dental applications.
  • Increased exposure has led to a rise in palladium sensitization among the general population.

Purpose of the Study:

  • To investigate the prevalence of palladium allergy within a US-based patient cohort undergoing patch testing.
  • To analyze the clinical manifestations associated with palladium sensitivity.

Main Methods:

  • A retrospective analysis of 910 patients tested for palladium sensitivity between 1997 and 2006.
  • Utilized palladium chloride 2% in petrolatum for patch testing.
  • Reviewed medical records of palladium-sensitive patients to identify associated conditions.

Main Results:

  • A palladium-positive patch test result was observed in 12.1% (110 out of 910) of the tested population.
  • Among 106 patients with palladium sensitivity, common diagnoses included stomatitis (27.4%), hand and body dermatitis (29.2%), lichen planus-like eruptions (15.1%), and burning mouth (13.2%).

Conclusions:

  • Palladium sensitivity appears more prevalent in oral conditions compared to skin conditions.
  • A significant co-reactivity between gold and palladium was observed, similar to the known co-reactivity with nickel, suggesting cross-reactivity potential.