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Related Experiment Video

Updated: Jun 19, 2026

Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory
07:59

Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory

Published on: June 14, 2019

KIBRA and CLSTN2 polymorphisms exert interactive effects on human episodic memory.

Claudia Preuschhof1, Hauke R Heekeren, Shu-Chen Li

  • 1Max Planck Institute for Human Development, Berlin, Germany. preuschhof@mpib-berlin.mpg.de

Neuropsychologia
|October 7, 2009
PubMed
Summary
This summary is machine-generated.

Genetic variations in KIBRA and CLSTN2 genes influence episodic memory. The KIBRA T-allele enhances memory, especially with associative demands, and this effect is amplified by the CLSTN2 C-allele.

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Last Updated: Jun 19, 2026

Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory
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09:38

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Published on: November 14, 2017

Area of Science:

  • Neuroscience
  • Behavioral Genetics

Background:

  • Episodic memory shows high heritability, with KIBRA gene polymorphisms linked to performance.
  • CLSTN2 gene results are inconsistent, suggesting potential gene interactions.

Purpose of the Study:

  • To investigate the interactive effects of KIBRA and CLSTN2 genes on episodic memory performance.
  • To explore how these genes, expressed in the medial temporal lobe, modulate synaptic plasticity and memory.

Main Methods:

  • Examined episodic memory performance in 383 participants.
  • Analyzed the interaction between KIBRA and CLSTN2 gene polymorphisms.

Main Results:

  • Replicated the KIBRA T-allele's positive effect on episodic memory, which increased with task associative demands.
  • Observed that the CLSTN2 C-allele boosted the KIBRA T-allele's memory-enhancing effect.
  • Found that the CLSTN2 C-allele reduced performance in individuals homozygous for the KIBRA C-allele.

Conclusions:

  • KIBRA and CLSTN2 genes interact to modulate episodic memory.
  • Highlights the importance of considering gene-gene interactions in understanding brain and behavior.