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Updated: Jun 19, 2026

In-vivo Detection of Protein-protein Interactions on Micro-patterned Surfaces
07:42

In-vivo Detection of Protein-protein Interactions on Micro-patterned Surfaces

Published on: March 19, 2010

Fast screening of protein surfaces using geometric invariant fingerprints

Shuangye Yin1, Elizabeth A Proctor, Alexey A Lugovskoy

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Genetics Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599-7260, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 7, 2009
PubMed

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...