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Updated: Jun 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
3-(1H-pyrrol-2-yl)-1H-pyrazole forms an unusual hydrogen-bonded two-dimensional (3,4)-connected net
Katie E R Marriott1, Colin A Kilner, Malcolm A Halcrow
1School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, England.
Abstract:
The title compound, C7H7N3, is the first crystallographically characterized 1H-pyrrolyl-1H-pyrazole derivative and contains two unique molecules in its asymmetric unit (Z' = 2). These molecules associate into centrosymmetric tetramers through N-H...N hydrogen bonding, including a cyclic dimerization of one of the two unique pyrazole rings. These tetramers are linked further by two weaker N-H...pi contacts to give a novel two-dimensional (3,4)-connected net with a (3(2).8)(2)(3.8(2))(2) topology.
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