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Related Experiment Video

Updated: Jun 19, 2026

Isolation of Intact, Whole Mouse Mammary Glands for Analysis of Extracellular Matrix Expression and Gland Morphology

Isolation of Intact, Whole Mouse Mammary Glands for Analysis of Extracellular Matrix Expression and Gland Morphology

Published on: October 30, 2017

Persistent Müllerian duct syndrome.

Neeraj Prakash¹, Anuj Khurana, Bhawna Narula

¹Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110 085, India.

Indian Journal of Pathology & Microbiology

|October 7, 2009

Summary

Persistent Müllerian duct syndrome (PMDS) is a rare condition where males have Müllerian duct remnants. This case highlights PMDS discovered incidentally in a cryptorchid male diagnosed with seminoma.

Area of Science:

Endocrinology
Genetics
Reproductive Medicine

Background:

Persistent Müllerian duct syndrome (PMDS) is a rare intersex condition.
It is characterized by the presence of Müllerian duct remnants in males who are otherwise genotypically and phenotypically normal.
PMDS is typically diagnosed in infancy or childhood, but late diagnosis is possible.

Observation:

A 40-year-old cryptorchid male presented with a clinical diagnosis of seminoma in his undescended abdominal testis.
Abdominal orchidectomy was performed for the suspected seminoma.
Histological examination revealed the presence of Müllerian duct structures.

Findings:

The histological findings confirmed a diagnosis of Persistent Müllerian duct syndrome (PMDS).

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This diagnosis was made in adulthood, despite the initial clinical presentation suggesting malignancy.

The case underscores the importance of thorough histological evaluation in cryptorchidism.

Implications:

This case expands the known clinical spectrum of Persistent Müllerian duct syndrome (PMDS).
It highlights the possibility of late diagnosis in adult males with undescended testes.
Accurate diagnosis of PMDS is crucial for appropriate management and genetic counseling.