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Effect of recombinant human growth hormone on random pattern flaps in rats
Avshalom Shalom1, Liora Hollander, Melvyn Westreich
1Department of Plastic Surgery, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel. fredricag@asaf.health.gov.il
Annals of Plastic Surgery
|October 7, 2009
Summary
Recombinant human growth hormone did not improve random flap survival in rats. However, it significantly increased weight gain and well-being, suggesting it is safe for use in flap surgery.
Area of Science:
- Biochemistry
- Surgical Research
- Endocrinology
Background:
- Recombinant human growth hormone (rhGH) is a potent anabolic hormone involved in growth, bone metabolism, and wound healing.
- Its role in surgical outcomes, particularly flap survival, requires further investigation.
Purpose of the Study:
- To evaluate the effect of recombinant human growth hormone on random flap survival in a rat model.
- To assess the safety and impact of rhGH on overall animal well-being during flap surgery.
Main Methods:
- Rats were randomly assigned to receive either rhGH (5 mg/kg subcutaneously) or a placebo.
- A dorsal random flap was surgically created.
- Flap survival and average rat weight were assessed after one week.
Main Results:
- No significant difference in random flap survival was observed between the rhGH-treated group and the control group.
- Rats treated with rhGH exhibited significantly greater weight gain compared to controls.
- No adverse effects on flap survival were noted with rhGH administration.
Conclusions:
- Recombinant human growth hormone does not enhance random flap survival.
- rhGH demonstrated a positive impact on rat weight gain and overall well-being.
- The findings support the potential safety of using rhGH during flap surgery.
