Related Experiment Video
Updated: Jun 19, 2026
09:58
A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
Published on: May 6, 2016
Cerebellopontine angle arachnoid cyst containing ectopic choroid plexus--case report
William G B Singleton1, Tim Lawrence, Alex L Green
1Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK. williamsingleton@doctors.org.uk
Acta Neurochirurgica
|October 7, 2009
Summary
A rare cerebellopontine angle cyst with ectopic choroid plexus was found in an adult female. Surgical removal confirmed choroid plexus in the cyst wall, marking the first such adult case.
Area of Science:
- Neurology
- Pathology
- Surgical Oncology
Background:
- Cerebellopontine angle (CPA) cysts are uncommon, typically benign lesions.
- Ectopic choroid plexus tissue is a rare developmental anomaly, usually found intracranially in children.
- This case explores an unusual presentation in an adult CPA.
Observation:
- A 26-year-old female presented with symptoms attributed to a CPA mass.
- Imaging revealed a cystic lesion in the cerebellopontine angle.
- Surgical intervention was performed for diagnosis and treatment.
Findings:
- Histological examination of the resected cyst confirmed the presence of ectopic choroid plexus tissue within the cyst wall.
- This represents the first documented instance of ectopic choroid plexus within a CPA cyst in an adult.
- The cyst was successfully resected with no reported complications.
Implications:
- This case expands the known spectrum of CPA lesions and ectopic tissue presentations.
- Highlights the importance of thorough histological evaluation for rare pathologies.
- May inform future diagnostic and surgical approaches for similar rare CPA cysts.
Related Concept Videos
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:19Cerebral Edema l: Introduction
Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...