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Published on: June 19, 2013
Lentiviral vectors in clinical trials: Current status
Jenice D'Costa1, S Gary Mansfield, Laurent M Humeau
1VIRxSYS Corp, Gaithersburg, MD 20877, USA.
Lentiviral vectors (LVs) show great promise for gene therapy due to their ability to infect various cells and provide long-term expression. This review highlights ongoing and planned clinical trials utilizing these advanced gene delivery systems.
Area of Science:
- Biotechnology
- Gene Therapy
- Viral Vector Technology
Background:
- Lentiviral vectors (LVs) are advanced viral-derived vectors for gene therapy.
- They can transduce both dividing and non-dividing cells, offering sustained transgene expression.
- LVs have become safer and more effective due to improved vector design and production.
Purpose of the Study:
- To review ongoing and planned clinical trials using lentiviral vectors for gene therapy.
- To highlight the therapeutic potential and advancements in LV-based treatments.
Main Methods:
- Review of clinical trial data and literature on lentiviral vector applications.
- Analysis of ongoing and planned gene therapy trials utilizing LVs.
Main Results:
- Lentiviral vectors are increasingly utilized in clinical trials since 2002.
- Trials target both infectious and genetic diseases, demonstrating broad applicability.
- Advances in LV technology have enhanced safety and efficacy.
Conclusions:
- Lentiviral vectors are a promising platform for gene therapy.
- Ongoing clinical trials underscore their therapeutic potential for various diseases.
- Continued development is expected to expand LV applications in medicine.
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