Related Experiment Video
Updated: Aug 12, 2026

The Successive Alleys Test of Anxiety in Mice and Rats
Published on: June 17, 2013
Efficacy of benzodiazepines in panic disorder and agoraphobia
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
Abstract:
Until recently, the benzodiazepines were believed to be ineffective in the treatment of panic disorder, with and without agoraphobic avoidance. Recent trials have shown, however, that panic disorder patients respond to benzodiazepines as well as to tricyclic antidepressants and monoamine oxidase (MAO) inhibitor antidepressants. Most of the controlled-trial investigations of benzodiazepines in panic disorder patients have evaluated the effects of alprazolam. However, early uncontrolled trials using other benzodiazepines have documented their effectiveness in panic disorder as well. This article reviews the evidence of the efficacy of alprazolam and other benzodiazepines in the treatment of panic disorder and their clinical use.
More Related Videos
11:18Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
Published on: September 12, 2014
05:42Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
Related Concept Videos
CNS Depressants: Barbiturates and Benzodiazepines
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Anxiolytic Drugs: Benzodiazepines and Buspirone
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Panic Disorder
Drug Therapy
Antianxiety Medications