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Updated: Jun 19, 2026
09:42
Generating Transgenics and Knockouts in Strongyloides Species by Microinjection
Published on: October 7, 2021
Strongyloidiasis in transplant patients.
Alison C Roxby1, Geoffrey S Gottlieb, Ajit P Limaye
1Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.
Summary
Strongyloides stercoralis hyperinfection syndrome is a deadly complication in transplant patients. Early screening and treatment before transplantation are crucial to prevent fatal outcomes in immunocompromised individuals.
Area of Science:
- Infectious Diseases
- Transplantation Immunology
- Parasitology
Background:
- Strongyloides stercoralis causes persistent infections, potentially leading to hyperinfection syndrome in immunocompromised hosts.
- Current guidelines advocate for pre-transplant screening and treatment of Strongyloides infection.
- Delayed diagnosis and high mortality characterize hyperinfection syndrome in transplant recipients.
Observation:
- A fatal case of Strongyloides hyperinfection syndrome occurred 2 months post-orthotopic heart transplantation.
- Physicians in the US frequently miss opportunities to diagnose chronic strongyloidiasis pre-transplant.
- Screening tests for Strongyloides have limitations, necessitating clinical suspicion.
Findings:
- Emphasis on pre-transplant screening and treatment is critical for preventing Strongyloides hyperinfection syndrome.
- Clinical suspicion is vital for evaluating transplant candidates for strongyloidiasis.
- Effective management of hyperinfection syndrome in transplant recipients requires prompt diagnosis and treatment.
Implications:
- Improved screening protocols and increased clinical awareness can reduce mortality from Strongyloides hyperinfection syndrome in transplant populations.
- Proactive management of Strongyloides infection in potential transplant recipients is essential for improving post-transplant outcomes.
- Further research into more sensitive diagnostic methods for Strongyloides is warranted for immunocompromised patients.
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