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Pneumococcal polysaccharide vaccine: cost-effectiveness recommendations in adults
1General Direction of Public Health, Departament de Salut, Direcció General de Salut Pública Travessera Corts 131159, Barcelona 08028, Spain. pedro.plans@gencat.net
Pneumococcal vaccination effectively prevents infections in high-risk groups. Cost-effectiveness supports recommending the vaccine for individuals over 64 and at-risk chronic patients.
Area of Science:
- Immunology
- Public Health
- Vaccinology
Background:
- Pneumococcal vaccination is a key strategy for preventing infections caused by Streptococcus pneumoniae.
- Previous studies demonstrated vaccine efficacy in the elderly and chronically ill, but recent trials show varied results in immunocompetent individuals.
Purpose of the Study:
- To review the cost-effectiveness of the 23-valent polysaccharide vaccine.
- To determine optimal recommendations for pneumococcal vaccination based on age and risk factors.
Main Methods:
- Systematic review of randomized clinical trials and case-control studies.
- Analysis of cost-effectiveness studies evaluating the 23-valent polysaccharide vaccine.
Main Results:
- Vaccination is cost-effective for individuals over 64 and at-risk chronic patients, with cost savings achieved if vaccine effectiveness exceeds 30%.
- For individuals aged 45-64 without risk factors, vaccination is recommended if cost-effectiveness is below €30,000 per life-year gained, requiring high vaccine effectiveness (over 90%) and specific pathogen prevalence.
Conclusions:
- Pneumococcal vaccination is recommended for all individuals over 64 and at-risk chronic patients.
- Vaccination may be beneficial for individuals aged 45-64 without risk factors under specific effectiveness and prevalence conditions.
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