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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

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Complications after treatment with polyalkylimide.

Leonie W Schelke¹, Helga J van den Elzen, Marijke Canninga

¹Medisch Laser Centrum, Amsterdam, The Netherlands. l.w.schelke@zonnet.nl

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]

|October 8, 2009

Summary

Polyalkylimide injections for soft tissue deficits can lead to significant complications like inflammation and hardening years later. Due to a 4.8% complication rate, its use is not recommended for cosmetic treatments.

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Area of Science:

Biomaterials Science
Dermatology
Plastic Surgery

Background:

Polyalkylimide is a biocompatible, nonresorbable polymer filler used for soft tissue augmentation.
Previous literature indicates a low initial complication rate for polyalkylimide treatments.
Delayed complications, appearing years post-injection, have been observed.

Purpose of the Study:

To comprehensively evaluate complications associated with polyalkylimide treatments.
To assess the long-term safety and adverse event profile of polyalkylimide fillers.

Main Methods:

A retrospective evaluation of complications was conducted.
Data were collected from members of the Dutch Society of Cosmetic Medicine.
Complications were analyzed based on patient and treatment rates.

Main Results:

A total of 3,196 patients and 4,738 treatments were reviewed.
154 complications were reported, resulting in a 4.8% patient complication rate and a 3.3% treatment complication rate.
The most frequent complications included inflammation, hardening, product migration, and accumulation; histological examination via skin biopsy was performed in some cases.

Conclusions:

Polyalkylimide treatments can result in complications manifesting years after administration.
The observed 4.8% overall complication rate, coupled with the severity and treatment challenges, poses an unacceptable risk for cosmetic procedures.
The Dutch Society of Cosmetic Medicine recommends against the use of polyalkylimide for cosmetic purposes.