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Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication
Published on: June 14, 2024
A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response
Ivana De Domenico1, Jerry Kaplan
1Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Abstract:
The unfolded protein response (UPR) coordinates translational and transcriptional changes triggered by unfolded proteins within the endoplasmic reticulum. Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity.
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