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Pemetrexed-induced pneumonitis: a case report
Yohann Loriot1, Charles Ferte, Carlos Gomez-Roca
1Department of Medicine, SITEP, Institut Gustave Roussy, Universite Paris XI, and Department of Pneumology, Hôpital Tenon, Marie Curie, Paris VI, France.
Abstract:
Pemetrexed is a structurally novel antifolate agent approved in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma who have unresectable disease and for the therapy of previously treated patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) as a single agent or in association with cisplatin as a first-line treatment in patients with nonsquamous histology. Herein, we report a case of pemetrexed-induced pneumonitis. Because pemetrexed is being prescribed with increasing frequency for NSCLC and mesothelioma, we believe that physicians should be aware of this rare but serious complication.
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