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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
Prevalence of left ventricular diastolic dysfunction in a general population
Tatiana Kuznetsova1, Lieven Herbots, Begoña López
1Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium. tatiana.kouznetsova@med.kuleuven.be
Circulation. Heart Failure
|October 8, 2009
Summary
Left ventricular diastolic dysfunction, a precursor to heart failure, affects nearly 27.3% of the general population. Risk factors include age, obesity, and hypertension, highlighting the need for early detection.
Area of Science:
- Cardiology
- Echocardiography
- Heart Failure Research
Background:
- Myocardial remodeling precedes heart failure symptoms.
- Guidelines emphasize early detection of subclinical left ventricular (LV) dysfunction.
- Identifying risk factors for heart failure is crucial.
Purpose of the Study:
- To determine the prevalence of LV diastolic dysfunction in the general population.
- To identify risk factors associated with LV diastolic dysfunction.
- To compare NT-proBNP levels in individuals with and without diastolic dysfunction.
Main Methods:
- Echocardiographic assessment of diastolic function in 539 participants.
- Tissue Doppler imaging and Doppler measurements of mitral inflow and pulmonary vein flow.
- Establishment of age-specific normal values using a healthy subsample.
Main Results:
- Prevalence of diastolic dysfunction was 27.3% (impaired relaxation: 9.8%, elevated filling pressure: 14.1%, combined: 3.4%).
- Elevated NT-proBNP levels were observed in impaired relaxation and elevated filling pressure groups.
- Risk factors included higher age, BMI, heart rate, systolic blood pressure, insulin, and creatinine.
Conclusions:
- LV diastolic dysfunction is prevalent in the general population.
- Echocardiographic assessment is key for identifying diastolic dysfunction.
- Risk factor management is essential for preventing heart failure progression.
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