Cervical carcinoma with adenoid cystic pattern: a light and electron microscopic study

Area of Science:

• Gynecologic Pathology
• Oncology
• Histopathology

Background:

• Adenoid cystic carcinoma (ACC) is a rare malignancy typically found in salivary glands.
• This study investigates three cases of cervical carcinoma exhibiting features of ACC.

Observation:

• Microscopic examination revealed a cribriform pattern with small cells and cystic lumina.
• Electron microscopy showed diverse cyst morphologies, including true gland-like lumina and extracellular spaces.
• Tumors displayed variability, with some showing cylindromatous formations and others associated with squamous cell carcinoma.

Findings:

• The histological and ultrastructural features of these cervical tumors are consistent with ACC found in other anatomical sites.
• Observed diversity in morphology suggests that ACC of the cervix may not represent a distinct histological entity.
• The presence of squamous cell carcinoma foci in two cases indicates potential differentiation or co-occurrence.

Implications:

• The findings support using the descriptive term "cervical carcinoma with adenoid cystic pattern" rather than a distinct classification.
• This terminology acknowledges the histological resemblance to ACC while accounting for observed morphological variations.
• Further research is warranted to fully understand the pathogenesis and behavior of this cervical lesion.