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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Published on: April 4, 2018

Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk

Lee E Moore1, Paul Brennan, Sara Karami

  • 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA. moorele@mail.nih.gov

Cancer Research
|October 8, 2009
PubMed
Summary

Genetic variations in APOE influence renal cell carcinoma (RCC) risk. Specific single nucleotide polymorphisms (SNPs) within the APOE promoter region were linked to increased susceptibility to this cancer. This suggests a role for lipid peroxidation pathways in RCC development.

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