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Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation
Masashi Mizuno1, Yosuke Nishitani, Takashi Hashimoto
1Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Japan. mizuno@kobe-u.ac.jp
Abstract:
A system for assessing the anti-inflammatory effects of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells and macrophage RAW264.7 cells. The results indicate that fucoidan and lentinan exhibited different suppressive effects on interleukin-8 (IL-8) mRNA expression in Caco-2 through tumor necrosis factor-alpha (TNF-alpha) production from RAW264.7 stimulated with lipopolysaccharide (LPS).