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Related Concept Videos

Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...

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Related Experiment Video

Updated: Jun 19, 2026

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
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Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

[Amitraz poisoning].

C Gustavo Caprotta1, Marcelo Martínez, Martín Tiszler

  • 1Unidad de Cuidados Intensivos Pediátricos, del Hospital de Trauma y Emergencias Dr. Federico Abete, Municipalidad de Malvinas Argentinas, Malvinas Argentinas, Buenos Aires. gcapro@gmail.com

Archivos Argentinos De Pediatria
|October 8, 2009
PubMed
Summary

Accidental amitraz poisoning in a child is rare but increasing in rural areas. Early recognition and intensive care, including mechanical ventilation, are crucial for managing this uncommon toxicity.

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Area of Science:

  • Toxicology
  • Pediatric Intensive Care

Background:

  • Amitraz is an insecticide and ectoparasiticide commonly used in rural settings.
  • Poisoning from amitraz, particularly in children, is infrequently documented, leading to limited physician guidance.

Observation:

  • A 2-year-old boy accidentally ingested amitraz and its solvent, xylene.
  • The child required admission to a Pediatric Intensive Care Unit and mechanical ventilation.

Findings:

  • Amitraz poisoning can lead to severe respiratory depression requiring ventilatory support.
  • Co-ingestion with solvents like xylene may exacerbate toxicity.

Implications:

  • This case highlights the need for increased physician awareness of amitraz poisoning in pediatric populations.
  • Prompt intensive care management is essential for favorable outcomes in childhood amitraz toxicity.