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Related Experiment Videos

Generalized morphea with blisters. A case report.

T Kobayasi1, A Willeberg, J Serup

  • 1Department of Dermatology, University of Copenhagen, Rigshospital, Denmark.

Acta Dermato-Venereologica
|January 1, 1990
PubMed
Summary
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Generalized morphea can cause blisters within skin plaques. These blisters are linked to degraded collagen and altered collagen types in the dermis.

Area of Science:

  • Dermatology
  • Pathology
  • Biochemistry

Background:

  • Generalized morphea is a rare autoimmune connective tissue disease characterized by localized sclerotic skin lesions.
  • Understanding the specific pathological changes within morphea plaques is crucial for diagnosis and treatment.

Observation:

  • A patient with generalized morphea presented with blisters developing within established morpheic plaques on the buttocks.
  • Ultrasound imaging revealed thickened skin and an increased echo response within the plaques.
  • Subepidermal echo-free bands were observed on ultrasound, corresponding to blister formation.

Findings:

  • Histopathological examination of the plaques showed compact collagen fibrils with a bimodal diameter distribution.
  • An increased concentration of serum aminoterminal propeptide of type III procollagen was detected.

Related Experiment Videos

  • Electron microscopy confirmed subepidermal blisters in the upper papillary dermis, associated with degraded collagen fibrils.

    • Implications:

    • This case highlights an unusual presentation of blistering in generalized morphea.
    • The findings suggest that collagen degradation and altered collagen composition play a role in blister formation within morphea plaques.
    • Further research is warranted to elucidate the mechanisms underlying blistering in morphea and its potential clinical significance.