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Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Updated: Jun 19, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

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Published on: November 15, 2024

Perfusion abnormalities in hemimegalencephaly.

P Wintermark1, E Roulet-Perez, M Maeder-Ingvar

  • 1Division of Neonatology, Department of Pediatrics, University Hospital (CHUV) and Lausanne Medical School, Lausanne, Switzerland.

Neuropediatrics
|October 8, 2009
PubMed
Summary
This summary is machine-generated.

Cerebrovascular changes in hemimegalencephaly (HM) may stem from vessel alterations, not just seizures. This case study highlights perfusion anomalies in a neonate with HM, suggesting a link to vascular development.

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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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Related Experiment Videos

Last Updated: Jun 19, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Neuroimaging

Background:

  • Cerebrovascular changes are infrequently explored in hemimegalencephaly (HM).
  • Previous research has linked these vascular alterations to epileptic activity.

Purpose of the Study:

  • To investigate cerebrovascular changes in a neonate with hemimegalencephaly.
  • To explore the relationship between perfusion anomalies and epileptical activity in HM.

Main Methods:

  • Case report of a neonate with total right hemimegalencephaly.
  • Utilized magnetic resonance imaging (MRI), including perfusion-weighted imaging, diffusion-tensor imaging, and AngioMRI.
  • Electroencephalogram (EEG) was performed to assess for seizures.

Main Results:

  • MRI revealed right hemisphere hypervascularization and abnormal white matter fiber arrangement.
  • AngioMRI demonstrated asymmetry in middle cerebral arteries, with the right side being prominent.
  • The neonate was seizure-free, with EEG showing asymmetric background activity but no electrical seizures.

Conclusions:

  • Perfusion anomalies in hemimegalencephaly may be associated with underlying vessel alterations.
  • These anomalies may not always correlate with epileptical activity.