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Updated: Jun 19, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
[Drug resistance in Mycobacterium tuberculosis during chronic intoxication by tobacco: clinical and experimental
Abstract:
Case histories were studied in 405 smoking patients (including 84 inveterate tobacco smokers) (a study group) and 193 nonsmoking patients (a control group) with new-onset pulmonary tuberculosis. Smoking was found to lead to a significant increase in the cases of drug resistance (including multidrug resistance (MDR)) in Mycobacterium tuberculosis (MBT): the resistant strains were 42.9% in the smokers and 54.4% in the inveterate tobacco smokers versus 31.9% in the control group (p < 0.01). The experiments showed that after two MBT strains (H37 Ra and 4688) had grown on the tobacco smoke condensate media, 57.1% of the experimental cultures were resistant to both one and several agents (including MDR), as shown by a study using the absolute concentration method.
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