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09:04
A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
Published on: June 1, 2022
Energy dissipation in slipping biological pumps
Signe Kjelstrup1, J Miguel Rubi, Dick Bedeaux
1Department of Chemistry, Faculty of Natural Science and Technology, Norwegian University of Science and Technology, Trondheim, 7491, Norway. signekj@phys.chem.ntnu.no
Physical Chemistry Chemical Physics : PCCP
|October 9, 2009
Summary
Active transport in biological pumps involves stochastic processes and energy dissipation. This study quantifies heat generation and cooling effects linked to pump function, offering insights into biological thermogenesis.
Area of Science:
- Biophysics
- Thermodynamics
- Cellular Biology
Background:
- Active transport is crucial for cellular function, involving the movement of molecules against concentration gradients.
- Biological pumps, like ATPases, drive this transport but their thermodynamic properties and associated thermal effects are not fully quantified.
Purpose of the Study:
- To describe active transport in biological pumps using mesoscopic nonequilibrium thermodynamics.
- To quantify the relationship between pump operation, energy dissipation, and thermal effects (heating/cooling).
- To estimate transport coefficients for calcium (Ca2+) transport via ATPase.
Main Methods:
- Application of mesoscopic nonequilibrium thermodynamics to model pump operation.
- Analysis of stochastic nature and energy dissipation in active transport.
- Utilizing published data for calcium transport by ATPase to determine transport coefficients.
Main Results:
- Demonstrated that pump operation is characterized by stochasticity and energy dissipation.
- Showed that both heating and cooling effects are associated with active pump function.
- Estimated key transport coefficients, including those linking ATP hydrolysis/synthesis to thermal effects.
Conclusions:
- The study provides a quantitative description of biological thermogenesis.
- All estimated coupling coefficients, particularly those related to thermal effects, were found to be significant.
- This framework offers a deeper understanding of the thermodynamics of active biological transport.
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