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Cells of the Epidermis

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jun 19, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Epidcermolytic hyperkeratosis: a case report.

Arun Achar¹, Biswanath Naskar, Rabindranath Laha

¹Department of Dermatology, Mednapore Medical College, Paschim Medinipur 721101.

Journal of the Indian Medical Association

|October 9, 2009

Summary

Epidermolytic hyperkeratosis, a rare genetic skin disorder, presents with blistering at birth and scaling later. This case highlights successful treatment using topical emollients with retinoids and systemic isotretinoin.

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Last Updated: Jun 19, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Dermatology
Genetics
Molecular Biology

Background:

Epidermolytic hyperkeratosis (EH) is a rare autosomal dominant genodermatosis.
It is characterized by generalized erythema, blisters, and erosions at birth, evolving into prominent hyperkeratosis and scaling.
Mutations in keratin 1 (KRT1) or keratin 10 (KRT10) genes cause EH.

Observation:

A rare case of epidermolytic hyperkeratosis in a 23-year-old male is presented.
The patient exhibited typical clinical features of the genodermatosis.

Findings:

Successful treatment was achieved using a combination therapy.
The treatment regimen included topical emollients with retinoids and systemic isotretinoin.

Implications:

This case demonstrates a viable therapeutic approach for epidermolytic hyperkeratosis.
The findings suggest that combined topical and systemic retinoid therapy can effectively manage this condition.