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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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Homocysteine--risk factor for ischemic stroke?

A P S Narang1, Indu Verma, Satinder Kaur

  • 1Department of Biochemistry, Dayanand Medical College & Hospital, Ludhiana 141 001. narang.aps@gmail.com

Indian Journal of Physiology and Pharmacology
|October 9, 2009
PubMed
Summary

Elevated homocysteine levels are significantly linked to ischemic stroke risk, independent of common factors like diabetes. This finding highlights homocysteine as a potential biomarker for stroke.

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Last Updated: Jun 19, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Clinical Biochemistry

Background:

  • Hyperhomocysteinemia, an elevation of homocysteine in the blood, is increasingly recognized as a potential risk factor for vascular diseases.
  • Ischemic stroke, a leading cause of disability and mortality, necessitates the identification of modifiable risk factors.

Purpose of the Study:

  • To investigate and compare serum homocysteine levels between patients diagnosed with ischemic stroke and a healthy control group.
  • To determine if elevated homocysteine levels in ischemic stroke patients are associated with other common risk factors such as diabetes mellitus, age, sex, and hypertension.

Main Methods:

  • A case-control study was conducted involving 117 patients with ischemic stroke and 101 age- and sex-matched controls.
  • Serum homocysteine levels were measured using a standard biochemical assay.
  • Statistical analysis, including t-tests and regression, was employed to compare homocysteine levels and assess associations with clinical variables.

Main Results:

  • Patients with ischemic stroke exhibited significantly higher mean homocysteine levels (16.80 ± 6.71 µmol/L) compared to controls (12.30 ± 4.68 µmol/L) (P < 0.01).
  • The elevated homocysteine levels in ischemic stroke patients were found to be independent of diabetes mellitus, age, and sex.
  • A statistically significant elevation in homocysteine was also observed in hypertensive subjects compared to non-hypertensive individuals (P < 0.05).

Conclusions:

  • Elevated serum homocysteine is a significant risk factor associated with ischemic stroke.
  • Homocysteine levels in ischemic stroke patients are not influenced by diabetes, age, or sex, suggesting a direct role in stroke pathogenesis.
  • Hypertension exacerbates homocysteine levels, further emphasizing the link between homocysteine and cerebrovascular health.